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Saxenda (liraglutide 3.0 mg) is a GLP-1 receptor agonist prescribed for weight management in adults with obesity or overweight with related health conditions. Whilst Saxenda sexual side effects are not officially documented in clinical trials or the Summary of Product Characteristics, some patients report changes in sexual function during treatment. These changes may relate indirectly to weight loss, gastrointestinal symptoms, hormonal shifts, or psychological factors rather than direct medication effects. Understanding the potential mechanisms and management strategies can help you maintain both your weight management goals and sexual wellbeing whilst using Saxenda.
Quick Answer: Saxenda (liraglutide) does not list sexual side effects in official documentation, though some patients report changes potentially linked to weight loss, gastrointestinal symptoms, or hormonal shifts.
Saxenda (liraglutide 3.0 mg) is a prescription medicine authorised in the UK for weight management in adults with obesity (BMI ≥30 kg/m²) or overweight (BMI ≥27 kg/m²) with weight-related health conditions such as type 2 diabetes, hypertension, or dyslipidaemia. It is administered as a once-daily subcutaneous injection and is intended to be used alongside a reduced-calorie diet and increased physical activity.
Saxenda belongs to a class of medications called glucagon-like peptide-1 (GLP-1) receptor agonists. It works by mimicking the action of GLP-1, a naturally occurring hormone that regulates appetite and food intake. The medication acts on specific receptors in the brain's appetite centres, particularly in the hypothalamus, to increase feelings of fullness (satiety) and reduce hunger. This helps patients consume fewer calories and achieve gradual, sustained weight loss.
Additionally, Saxenda slows gastric emptying, meaning food remains in the stomach longer, which contributes to prolonged satiety after meals. It also influences insulin secretion in a glucose-dependent manner, though its primary indication is weight management rather than glycaemic control. People with type 2 diabetes taking sulfonylureas or insulin may have an increased risk of hypoglycaemia when using Saxenda.
Clinical trials (SCALE programme) have demonstrated that when combined with lifestyle modifications, Saxenda can lead to clinically significant weight loss—typically 5–10% of initial body weight over one year. Treatment should be discontinued if at least 5% of initial body weight has not been lost after 12 weeks on the full 3.0 mg daily dose.
In the UK, NICE recommends liraglutide 3.0 mg for use within specialist weight management services for adults with a BMI of at least 35 kg/m² (or ≥32.5 kg/m² for certain ethnic groups) and weight-related comorbidities, or a BMI of at least 40 kg/m² without comorbidities. Understanding how Saxenda works helps contextualise potential side effects, including those that may indirectly affect sexual function.
There is no official, direct link between Saxenda and sexual side effects in the product's Summary of Product Characteristics (SmPC) or major clinical trials. Sexual dysfunction is not listed among the common, uncommon, or rare adverse reactions associated with liraglutide in the MHRA/eMC SmPC. However, patients occasionally report changes in sexual function or libido whilst taking weight-loss medications, and it is important to understand the potential indirect mechanisms.
Weight loss itself can influence sexual function in complex ways. For many individuals, significant weight reduction improves body image, self-esteem, and cardiovascular health, which may enhance sexual confidence and performance. Research suggests that weight loss often leads to improvements in sexual function, particularly in those with obesity-related health conditions. Conversely, rapid or substantial weight loss can temporarily affect hormone levels, energy levels, and mood, potentially impacting libido or sexual desire during the adjustment period.
Gastrointestinal side effects are among the most common adverse reactions to Saxenda, including nausea, vomiting, diarrhoea, and constipation. These symptoms, particularly if persistent or severe, can reduce overall wellbeing, energy, and interest in sexual activity. Feeling unwell or experiencing digestive discomfort may indirectly affect intimate relationships and sexual desire.
Hormonal changes associated with weight loss may also play a role. Adipose tissue is metabolically active and influences sex hormone production and regulation. Significant fat loss can alter oestrogen and testosterone levels, which are crucial for sexual function in both men and women. Additionally, caloric restriction and the metabolic stress of weight loss can temporarily affect the hypothalamic-pituitary-gonadal axis.
Psychological factors should not be overlooked. Starting a new medication, adjusting to lifestyle changes, and managing expectations around weight loss can create stress or anxiety, which are well-recognised contributors to reduced sexual desire or performance. It is essential to consider the broader context of each individual's health and circumstances when evaluating potential sexual side effects.
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If you experience changes in sexual function whilst taking Saxenda, several practical strategies may help manage these concerns whilst continuing your weight management programme.
Optimise medication tolerance: Many gastrointestinal side effects improve over time as your body adjusts to Saxenda. Following the recommended dose escalation schedule—starting at 0.6 mg daily and increasing by 0.6 mg weekly to the maintenance dose of 3.0 mg—can minimise adverse effects. If side effects are troublesome, you can delay dose increases or step back to the previous tolerated dose after discussing with your healthcare provider. Taking your injection at a consistent time each day and ensuring adequate hydration may also reduce nausea and digestive discomfort. Smaller, more frequent meals and limiting high-fat foods can help manage gastrointestinal symptoms.
Maintain balanced nutrition: Whilst caloric restriction is necessary for weight loss, ensure your diet provides adequate nutrients, including healthy fats, which are important for hormone production. Severe caloric deficits can exacerbate hormonal changes and fatigue. Working with a registered dietitian can help you achieve weight loss goals whilst supporting overall health, energy levels, and hormonal balance.
Prioritise sleep and stress management: Both are crucial for sexual health and overall wellbeing. Weight loss programmes can be demanding, and inadequate rest or chronic stress can suppress libido and sexual function. Aim for 7–9 hours of quality sleep nightly and consider stress-reduction techniques such as mindfulness, yoga, or regular physical activity.
Communicate with your partner: Open, honest communication about changes you're experiencing can reduce anxiety and strengthen intimacy. Your partner's understanding and support can be invaluable during this adjustment period.
Monitor your progress: Keep a symptom diary noting when sexual changes occur, their severity, and any patterns related to medication timing, diet, or stress levels. This information will be valuable if you need to discuss concerns with your GP or healthcare provider.
Note that Saxenda is not recommended during pregnancy or breastfeeding. If you are of childbearing potential, discuss appropriate contraception with your healthcare provider, and discontinue Saxenda immediately if pregnancy occurs.
Whilst sexual side effects are not commonly reported with Saxenda, any persistent or concerning changes warrant discussion with your GP or prescribing healthcare professional. Do not stop taking Saxenda abruptly without medical guidance, as this should be done under supervision as part of your overall treatment plan.
Seek urgent medical attention (call NHS 111, visit A&E, or call 999 in emergencies) if you experience:
Severe, persistent abdominal pain which may radiate to your back (possible sign of pancreatitis)
Pain in the upper right side of your abdomen, fever, or yellowing of skin/eyes (possible gallbladder problems)
Signs of severe dehydration (extreme thirst, dizziness, dark urine, reduced urination)
Signs of allergic reaction (rash, swelling, difficulty breathing)
Contact your GP if you experience:
Persistent or worsening sexual dysfunction that significantly affects your quality of life or relationships
Severe gastrointestinal symptoms (persistent nausea, vomiting, or diarrhoea) that may be contributing to reduced wellbeing
Signs of hormonal imbalance, such as irregular menstrual periods, unexpected hair loss, or significant mood changes
Symptoms of depression or anxiety, including persistent low mood, loss of interest in activities you previously enjoyed, or excessive worry
Extreme fatigue or weakness that limits daily activities
Any other unexpected or concerning symptoms whilst taking Saxenda
Your GP can conduct a thorough assessment to determine whether symptoms are related to Saxenda, weight loss, underlying health conditions, or other factors. They may recommend blood tests to evaluate hormone levels, thyroid function, or nutritional status. In some cases, adjusting the Saxenda dose, addressing contributing factors, or considering alternative weight management strategies may be appropriate.
Remember that Saxenda should be discontinued if you have not lost at least 5% of your initial body weight after 12 weeks on the full 3.0 mg dose, as per the SmPC guidance.
NICE guidance emphasises that liraglutide 3.0 mg should be prescribed as part of a comprehensive programme within specialist weight management services, including dietary advice, physical activity support, and behavioural interventions. Your healthcare team can help optimise all aspects of your treatment plan to maximise benefits whilst minimising adverse effects.
If you believe you have experienced a side effect from Saxenda, you can report it directly to the MHRA through the Yellow Card scheme at yellowcard.mhra.gov.uk or via the Yellow Card app.
Sexual dysfunction is not listed as an adverse reaction in Saxenda's official documentation or clinical trials. Any reported changes are likely indirect, relating to weight loss, gastrointestinal symptoms, hormonal shifts, or psychological factors rather than direct medication effects.
Yes, significant weight loss can influence sexual function through multiple mechanisms, including changes in sex hormone levels, energy, mood, and body image. For many, weight loss improves sexual confidence, whilst others may experience temporary changes during the adjustment period.
Contact your GP if you experience persistent sexual dysfunction affecting quality of life, severe gastrointestinal symptoms, signs of hormonal imbalance (irregular periods, mood changes), or extreme fatigue. Your GP can assess whether symptoms relate to Saxenda, weight loss, or other factors and recommend appropriate management.
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DisclaimerThis content is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional with any medical questions or concerns. Use of the information is at your own risk, and we are not responsible for any consequences resulting from its use.
